Clinical Endocrinology & Metabolism

 Genetic and non iodine-related factors in the cause of nodular goitre
Genetic and a large number of environmental non-iodine-related factors play a role in the cause of nodular goitre. Most evidence for the influence of genetic and environmental factors in the cause of goitre is from cross-sectional, population-based studies. Only a few studies have included prospective data on risk factors for nodular goitre, although few prospective data are available on the effect of iodine and tobacco smoking on goitre development. When studying this issue, it is important to realize that goitre is not one single phenotype.