Clinical Endocrinology & Metabolism

 Chemotherapy and tyrosine-kinase inhibitors for medullary thyroid cancer
Medullary thyroid cancer (MTC) represents 3% of all clinical thyroid cancers and arises from thyroid C cells that produce calcitonin. Locally advanced or metastatic MTC requires a careful work-up including measurement of serum calcitonin and carcinoembryonic antigen, determination of their doubling time and comprehensive imaging to determine the extent of the disease, its aggressiveness, and the need for treatment.Cytotoxic chemotherapy can control tumor burden in some patients with response rates of around 20% in old series.